Share Under Selection
A major result in the Mouse genome paper was my estimate of the share of the human genome under purifying selection. I developed score functions to detect unusually conserved regions in the human genome by comparing it to the mouse. By looking at the distribution of conservation scores genome-wide compared to the scores of regions under neutral section, I estimated that 5% of human genome is under purifying selection. This percentage is much higher than the fraction of the genome that codes for proteins and spurred new interest in function non-coding elements of the human genome.